Paul Marquardt has produced digitally composed images, responsive installations, interactive performances, and internet-based art, as well as sculpture, drawing, photography, printmaking, and painting. He has collaborated with choreographers and composers, creating interactive sets, sound structures, and unique computer interfaced musical instruments such as his "midi chairs" used by choreographer Patricia Plasko and composer Stephen Rush at the Toronto Fringe Festival of Independent Dance Artists and by the University of Michigan Digital Music Ensemble.

Marquardt has a Bachelor of Arts in music and philosophy and a Bachelor of Fine Arts in visual arts from Western Michigan University, as well as an Masters of Fine Arts in visual arts from Ohio University. He has taught at The University of Michigan, Albion College, Eastern Connecticut State University, Western Michigan University, and Kendall College of Art & Design.  Marquardt worked with Education for the Arts to establish the New Media program, which offers advanced arts & technology courses to high school students in the Kalamazoo region where he currently lives.

Marquardt's artwork has been exhibited across the United States, including at the Catherine Edelman Gallery in Chicago, the Detroit Museum of New Art, the 17th National Photography in Colorado, Gallery Project in Ann Arbor, Print Biennial IV in Chicago, and SOHO PHOTO in New York. His international showings include the Leo Kamen Gallery and Fida in Toronto and the International Society of Electronic Artists in Paris.

His commissions include artworks for Western Michigan University, Bronson Health Group, VML marketing, Wellspring Cory Terry & Dancers, and The University of Michigan.